New research reveals that individuals who discontinue popular GLP-1 drugs like Wegovy and Mounjaro can put back on shed pounds much more quickly than those who stop conventional diet and exercise programs.
Findings released in a leading health publication shows that while obese individuals often shed about a fifth of their total mass while on the medication, the weight returns at an average rate of nearly a kilo each month once they quit.
"Users using such treatments need to be informed of the risk of quick weight regain when the therapy ends," stated researcher Dr. Susan Jebb.
This pace of recovery suggests a reversion to original mass within about one and a half years.
Weighing Therapies
The research, which looked at dozens of trials involving thousands of participants, compared the outcomes of these new drugs with other pills.
The team point out that individuals who lose weight through diet and exercise typically see a less rapid creep back—approximately 100 grams monthly—after stopping.
Explaining the Rapid Rebound
Experts propose the mechanism of the jabs explains the accelerated rebound.
GLP-1 drugs copy a body's own chemical called GLP-1, which helps regulate appetite.
"Sustained high doses of the hormone levels far above than normal may cause the body to generate a reduced amount of its endogenous hormone, and could lessen sensitivity to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication leads to appetite is unsuppressed, making binge eating a significant risk."
An Ongoing Disease?
Medical guidelines recommend the injections for people with obesity-related medical conditions, alongside prescribed lifestyle changes.
A number of clinicians contend that, considering the high risk of weight regain, the therapy should be considered long-term.
This opinion is supported by drug manufacturers, who note that the results "emphasize the persistent nature of excess weight," comparing it to managing diseases like hypertension.
User Experiences
People who have stopped the jabs explain a intense resurgence of appetite.
"I experienced something that goes on and you become starving," described one woman.
The struggle is worsened if patients have not established permanent lifestyle or habit changes during treatment.
Growing Adoption
Survey data suggest that millions of people in the UK have used weight-loss jabs in the last 12 months, with interest continuing to grow.
- Use is higher among females compared to men.
- The middle-aged age group shows the highest usage rates.
- Many obtain the medications through private healthcare rather than public health services.
In conclusion, clinicians stress that while these medications are effective agents for shedding pounds, they are not a magic fix and long-term success hinges on combined lifestyle support.
